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山 奈酚

分析標(biāo)準(zhǔn)品,HPLC≥98%

Kaempferol

CAS號：520-18-3

分子式：C15H10O6

分子量：286.24

MDL：MFCD00016938

別名：莰菲醇，山nai酚-3，山 柰黃酮醇，四羥基黃酮， 百蕊草素Ⅲ

產(chǎn)品介紹

Kaempferol (Kempferol) 在乳腺癌細(xì)胞中抑制雌激素受體 (estrogen receptor α) 表達(dá)，在膠質(zhì)母細(xì)胞瘤細(xì)胞和肺癌細(xì)胞中，通過激活 MEK-MAPK 誘導(dǎo)細(xì)胞凋亡。Kaempferol 可用于乳腺癌研究。

熔點(diǎn)：276℃

沸點(diǎn)：582.1 ℃ at 760 mmHg

外觀：黃色粉末

溶解性：DMSO:≥32mg/mL(111.79mM)

H2O:<0.1mg/mL(ultrasonic;warming;heatto 60℃)(insoluble)

儲(chǔ)存條件：-20℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(398篇)

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281. [IF=6.1] Shuxin Tang et al."Hypoglycemic effect of Lactobacillus plantarum-fermented mulberry pomace extract in vitro and in Caenorhabditis elegans."Food & Function.10.1039/D3FO02386A

280. [IF=3.9] Zhi-Ting Liu et al."Optimization of ultrasound-assisted extraction of flavonoids from Portulaca oleracea L., the extraction kinetics and bioactivity of the extract."Journal of Applied Research on Medicinal and Aromatic Plants.2023 Aug;:100512

279. [IF=4.9] Zhang Min et al."Discovery and evaluation of active compounds from Xuanfei Baidu formula against COVID-19 via SARS-CoV-2 Mpro."Chinese Medicine.2023 Dec;18(1):1-14

278. [IF=5.2] Yujie Xie et al."Camellia oleifera seeds cake: Polyphenol profile and in vitro antioxidant activities as determined by different harvest periods."Food Bioscience.2023 Oct;55:103081

277. [IF=3.3] Jian Li et al."Rapid Analysis of 18 Flavonoids in Tea by Ultrahigh-Performance Liquid Chromatography Coupled with Quadrupole-Time of Flight Mass Spectrometry."JOURNAL OF FOOD QUALITY.2023;2023:3940081

276. [IF=4.6] Fengge YANG et al."Deciphering chemical and metabolite profiling of Chang-Kang-Fang by UPLC-Q-TOF-MS/MS and its potential active components identification."Chinese Journal of Natural Medicines.2023 Jun;21:459

275. [IF=4.6] Zhongjing Zhou et al."Quantitative Analysis of Flavonoids in Fruiting Bodies of Sanghuangporus Using Ultra-High-Performance Liquid Chromatography Coupled with Triple Quadrupole Mass Spectrometry."MOLECULES.2023 Jan;28(13):5166

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272. [IF=6.1] Xiaoxi Zhang et al."Kaempferol Exerts the Thermogenic Function of Adipocytes in High-Fat-Diet-Induced Obesity by Regulating the CDK6/RUNX1/UCP1 Signaling Pathway."Food & Function.2023 Jul;:

271. [IF=6.1] Chenxi XIA et al."Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) restore CUMS-induced depressive disorder and regulate gut microbiota in mice."Food & Function.2023 Jul;:

270. [IF=8.8] Guitao Huang et al."Divergent metabolism of two lychee (Litchi chinensis Sonn.) pulp flavonols and their modulatory effects on gut microbiota: Discovery of hydroxyethylation in vitro colonic fermentation."FOOD CHEMISTRY.2023 Dec;429:136875

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268. [IF=7.5] Na Li et al."Kaempferol attenuates nonalcoholic fatty liver disease in type 2 diabetic mice via the Sirt1/AMPK signaling pathway."BIOMEDICINE & PHARMACOTHERAPY.2023 Sep;165:115113

267. [IF=1.7] Zhouyi Zhang et al."Revealing the differences in phenolics in different parts of Taraxacum mongolicum using UPLC-MS/MS."Phytochemistry Letters.2023 Aug;56:13

266. [IF=3.5] Hongmei Yin et al."Optimization of Cellulase-Assisted Extraction of Total Flavonoids from Equisetum via Response Surface Methodology Based on Antioxidant Activity."Processes.2023 Jul;11(7):1978

265. [IF=5] Hao Junfeng et al."Optimization of ultrasonic-assisted extraction of flavonoids from Lactuca indica L. cv. Mengzao and their antioxidant properties."Frontiers in Nutrition.2023 Jun;10:

264. [IF=5.2] Zhuanrong Wu et al."Effects of Sun Withering Degree on Black Tea Quality Revealed via Non-Targeted Metabolomics."Foods.2023 Jan;12(12):2430

263. [IF=5.6] Ruyang Yu et al."Kaempferol relieves the DSS-induced chronic colitis in C57BL/6J mice, alleviates intestinal angiogenesis, and regulates colonic microflora structure."Journal of Functional Foods.2023 Aug;107:105646

262. [IF=6.6] Lishuang Zhang et al."Flavonol synthase gene MsFLS13 regulates saline-alkali stress tolerance in alfalfa."Crop Journal.2023 Jun;:

261. [IF=7.9] Junwei Gao et al."Kaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion."PHYTOMEDICINE.2023 Sep;118:154942

260. [IF=8.1] Ziwei Wang et al."Comparative antioxidant activity and untargeted metabolomic analyses of cherry extracts of two Chinese cherry species based on UPLC-QTOF/MS and machine learning algorithms."FOOD RESEARCH INTERNATIONAL.2023 Sep;171:113059

259. [IF=8.8] Jing Yang et al."Discovery and verification of bitter components in Panax notoginseng based on the integrated strategy of pharmacophore model, system separation and bitter tracing technology."FOOD CHEMISTRY.2023 Dec;428:136716

258. [IF=8.8] Lijuan Zhu et al."Browning inhibition in fresh-cut Chinese water chestnut under high pressure CO2 treatment: regulation of reactive oxygen species and membrane lipid metabolism."FOOD CHEMISTRY.2023 Jun;:136586

257. [IF=3.776] Lele Zhang et al."Integration of UHPLC/Q-OrbitrapMS-based metabolomics and activities evaluation to rapidly explore the anti-inflammatory components from lasianthus.."Heliyon.2023 May;9(6):e16117-e16117

256. [IF=4.125] Lei Ma et al."Comparison of the effect of extraction methods on the waste cotton (Gossypium hirsutum L ) flowers: metabolic profile, bioactive components, antioxidant, and α-amylase inhibition."JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE.2023 May;:

255. [IF=5.195] Haotian Zhang et al."Spectrum-effect relationship study to reveal the pharmacodynamic substances in Flos Puerariae-Semen Hoveniae medicine pair for the treatment of alcohol-induced liver damage."JOURNAL OF ETHNOPHARMACOLOGY.2023 Oct;314:116628

254. [IF=6.056] Qianqian Chu et al."Effect mechanism of different drying methods on the quality and browning for daylily."LWT-FOOD SCIENCE AND TECHNOLOGY.2023 Jun;182:114862

253. [IF=6.208] Xiaoshan Chen et al."BcMYB111 Responds to BcCBF2 and Induces Flavonol Biosynthesis to Enhance Tolerance under Cold Stress in Non-Heading Chinese Cabbage."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2023 Jan;24(10):8670

252. [IF=6.269] Shiye Lin et al."The stability and degradation products of polyhydroxy flavonols in boiling water."Current Research in Food Science.2023 May;:100509

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250. [IF=6.449] Yuanyue Wang et al."A novel flavonoid prenyltransferase gene PcPT11 with broad substrate promiscuity in Psoralea corylifolia L.."INDUSTRIAL CROPS AND PRODUCTS.2023 Sep;199:116746

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248. [IF=7.425] Xinlong Cheng et al."Cabernet sauvignon dry red wine ameliorates atherosclerosis in mice by regulating inflammation and endothelial function, activating AMPK phosphorylation, and modulating gut microbiota."FOOD RESEARCH INTERNATIONAL.2023 Jul;169:112942

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245. [IF=4.52] Yue-Yue Chang et al."Targeted metabolites analysis and variety discrimination of Wuyi rock tea by using a whole-process chemometric-assisted HPLC-DAD strategy."JOURNAL OF FOOD COMPOSITION AND ANALYSIS.2023 Aug;121:105365

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241. [IF=6.656] Chen-Xi Xia et al."Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) mimic neurotrophic functions in inducing neurite outgrowth in cultured neurons: Signaling via PI3K/Akt and ERK pathways."PHYTOMEDICINE.2023 Jul;115:154832

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239. [IF=9.231] Lin Han et al."Inhibition mechanism of α-glucosidase inhibitors screened from Tartary buckwheat and synergistic effect with acarbose."FOOD CHEMISTRY.2023 Sep;420:136102

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236. [IF=3.612] Ren Li et al."The combined effect of cold plasma pretreatment and germination on nutritional quality and texture properties of brown rice cakes."INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY.2023 Mar;:

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194. [IF=2.863] Jue Cui et al."Burdock (Arctium lappa L.) leaf flavonoids rich in morin and quercetin 3-O-rhamnoside ameliorate lipopolysaccharide-induced inflammation and oxidative stress in RAW264.7 cells."Food Science & Nutrition

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192. [IF=2.63] Li Hangchao et al."Bushen Jianpi Quyu Formula Alleviates Myelosuppression of an Immune-Mediated Aplastic Anemia Mouse Model via Inhibiting Expression of the PI3K/AKT/NF-κB Signaling Pathway."Evidence-based Complementary and Alternative Medicine. 2022;2022:

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185. [IF=4.412] Haifan Liu et al."Pharmacokinetics, Prostate Distribution and Metabolic Characteristics of Four Representative Flavones after Oral Administration of the Aerial Part of Glycyrrhiza uralensis in Rats."MOLECULES. 2022 Jan;27(10):3245

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182. [IF=7.46] Shuo Wang et al."A novel visual sensing method based on Al@AuNCs for rapid identification of Chrysanthemum morifolium from different origins."Sensor Actuat B-Chem. 2022 Apr;356:131307

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172. [IF=4.987] Shang  Xian-chao et al."Temperature-responsive deep eutectic solvents as eco-friendly and recyclable media for microwave extraction of flavonoid compounds from waste onion (Allium cepa L.) skins."Biomass Convers Bior. 2022 Feb;:1-10

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167. [IF=5.34] Yule Wang et al."Guhong injection promotes post-stroke functional recovery via attenuating cortical inflammation and apoptosis in subacute stage of ischemic stroke."Phytomedicine. 2022 May;99:154034

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161. [IF=1.77] Muhammad  Khalid et al."Suppression of clubroot (Plasmodiophora brassicae) development in Brassica campestris sp. chinensis L. via exogenous inoculation of Piriformospora indica."J Radiat Res Appl Sc. 2020;13(1):180-190

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137. [IF=4.36] Mingliang Gao et al."Evaluation of VEGF mediated pro-angiogenic and hemostatic effects and chemical marker investigation for Typhae Pollen and its processed product."J Ethnopharmacol. 2021 Mar;268:113591

136. [IF=4.36] Peng-yu Chen et al."Revealing the mechanism of “Huai Hua San" in the treatment of ulcerative colitis based on network pharmacology and experimental study."J Ethnopharmacol. 2021 Dec;281:114321

135. [IF=4.36] Li Lin et al."Study on the alleviation of Fengshi Gutong capsule on rheumatoid arthritis through integrating network pharmacology and experimental exploration."J Ethnopharmacol. 2021 Nov;280:114471

134. [IF=4.411] Zong-Jin Pu et al."The Comprehensive Evaluation of Safflowers in Different Producing Areas by Combined Analysis of Color, Chemical Compounds, and Biological Activity."Molecules. 2019 Jan;24(18):3381

133. [IF=4.411] Ning Jin et al."Comprehensive Evaluation of Amino Acids and Polyphenols in 69 Varieties of Green Cabbage (Brassica oleracea L. var. capitata L.) Based on Multivariate Statistical Analysis."Molecules. 2021 Jan;26(17):5355

132. [IF=4.599] Guo  Ying et al."Temporospatial Flavonoids Metabolism Variation in Ginkgo biloba Leaves."Front Genet. 2020 Nov;0:1503

131. [IF=4.769] Yuan Hong et al."Determination of bioactive components in the fruits of Cercis chinensis Bunge by HPLC-MS/MS and quality evaluation by principal components and hierarchical cluster analyses."J Pharm Anal. 2021 Aug;11:465

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129. [IF=4.952] Zhiqiang Hou et al."Processing of chestnut rose juice using three-stage ultra-filtration combined with high pressure processing."Lwt Food Sci Technol. 2021 May;143:111127

128. [IF=4.952] Yuxin Hao et al."Stability and mechanism of phenolic compounds from raspberry extract under in vitro gastrointestinal digestion."Lwt Food Sci Technol. 2021 Mar;139:110552

127. [IF=4.952] Shuxin Tang et al."Effect of Lactobacillus plantarum-fermented mulberry pomace on antioxidant properties and fecal microbial community."Lwt Food Sci Technol. 2021 Jul;147:111651

126. [IF=5.11] Xiaonan Liu et al."De Novo Biosynthesis of Multiple Pinocembrin Derivatives in Saccharomyces cerevisiae."Acs Synth Biol. 2020;9(11):3042–3051

125. [IF=5.279] Qinggang Yin et al."Identification of Specific Glycosyltransferases Involved in Flavonol Glucoside Biosynthesis in Ginseng Using Integrative Metabolite Profiles, DIA Proteomics, and Phylogenetic Analysis."J Agr Food Chem. 2021;69(5):1714–1726

124. [IF=5.645] Ying Guo et al."Spatial prediction and delineation of Ginkgo biloba production areas under current and future climatic conditions."Ind Crop Prod. 2021 Aug;166:113444

123. [IF=5.645] Ying Guo et al."Metabolome and transcriptome analyses reveal flavonoids biosynthesis differences in Ginkgo biloba associated with environmental conditions."Ind Crop Prod. 2020 Dec;158:112963

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121. [IF=6.023] Mengxue Diao et al."Enhanced cytotoxicity and antioxidant capacity of kaempferol complexed with α-lactalbumin."Food Chem Toxicol. 2021 Jul;153:112265

120. [IF=6.023] Maiquan Li et al."Discovery of Keap1?Nrf2 small?molecule inhibitors from phytochemicals based on molecular docking."Food Chem Toxicol. 2019 Nov;133:110758

119. [IF=6.081] Tongji Liu et al."Improvement Effect of Lotus Leaf Flavonoids on Carbon Tetrachloride-Induced Liver Injury in Mice."Biomedicines. 2020 Feb;8(2):41

118. [IF=6.306] Wei Yang et al."Liquid chromatography–mass spectrometry-based metabolomics analysis of flavonoids and anthraquinones in Fagopyrum tataricum L. Gaertn. (tartary buckwheat) seeds to trace morphological variations."Food Chem. 2020 Nov;331:127354

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116. [IF=6.529] Qi Huang et al."Systematic investigation of the pharmacological mechanism for renal protection by the leaves of Eucommia ulmoides Oliver using UPLC-Q-TOF/MS combined with network pharmacology analysis."Biomed Pharmacother. 2021 Aug;140:111735

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114. [IF=7.514] Yuan Cheng et al."Dual effects of quercetin on protein digestion and absorption in the digestive tract."Food Chem. 2021 Oct;358:129891

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111. [IF=9.147] Jianzhong Zhu et al."Effect of Rosa Roxburghii juice on starch digestibility: A focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling."Food Hydrocolloid. 2022 Feb;123:106966

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109. [IF=1.984] Zhu Hao et al."Anti-Inflammatory Effects of p-Coumaric Acid, a Natural Compound of Oldenlandia diffusa, on Arthritis Model Rats."Evid-Based Compl Alt. 2018;2018:5198594

108. [IF=1.984] Zhu Hao et al."Anti-Inflammatory Effects of the Bioactive Compound Ferulic Acid Contained in Oldenlandia diffusa on Collagen-Induced Arthritis in Rats."Evid-Based Compl Alt. 2014;2014:573801

107. [IF=2.408] Ji-Xiao Zhu et al."Quercetin, Kaempferol and Isorhamnetin in Elaeagnus pungens Thunb. Leaf: Pharmacological Activities and Quantitative Determination Studies."Chem Biodivers. 2018 Aug;15(8):e1800129

106. [IF=2.411] Wenqi Gao et al."Antidepressive effects of kaempferol mediated by reduction of oxidative stress, proinflammatory cytokines and up-regulation of AKT/β-catenin cascade."Metab Brain Dis. 2019 Apr;34(2):485-494

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86.  Zhang, Cao, et al. "Chemical structures of polyphenols that critically influence the toxicity of ZnO nanoparticles." Journal of agricultural and food chemistry 66.7 (2018): 1714-1722.https:##doi.org/10.1021/acs.jafc.8b00368

85.  Yang, Jing, et al. "Comparisons of the active components in four unripe raspberry extracts and their activites." Food Science and Technology 39 (2019): 632-639.https:##doi.org/10.1590/fst.27418

84.  Lyu, Yunbin, et al. "Identification and characterization of three flavonoid 3-O-glycosyltransferases from Epimedium koreanum Nakai." Biochemical Engineering Journal 163 (2020): 107759.https:##doi.org/10.1016/j.bej.2020.107759

83.  Yang, Wei, et al. "Liquid chromatography–mass spectrometry-based metabolomics analysis of flavonoids and anthraquinones in Fagopyrum tataricum L. Gaertn.(tartary buckwheat) seeds to trace morphological variations." Food chemistry 331 (2020): 127354.https:/

82.  Gao, Mingliang, et al. "Evaluation of VEGF mediated pro-angiogenic and hemostatic effects and chemical marker investigation for Typhae Pollen and its processed product." Journal of Ethnopharmacology 268 (2021): 113591.https:##doi.org/10.1016/j.jep.2020.113

81.  Zhu, Hao, et al. "Anti-inflammatory effects of p-coumaric acid, a natural compound of Oldenlandia diffusa, on arthritis model rats." Evidence-Based Complementary and Alternative Medicine 2018 (2018).https:##doi.org/10.1155/2018/5198594

80.  Liu, Huan, et al. "Antimicrobial activity and virulence attenuation of citral against the fish pathogen Vibrio alginolyticus." Aquaculture 515 (2020): 734578.https:##doi.org/10.1016/j.aquaculture.2019.734578

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78.  Shasha Jing, Huijun Zheng, Li Zhao, Lingbo Qu, Lanlan Yu,

A novel electrochemical sensor based on WO3 nanorods-decorated poly(sodium 4-styrenesulfonate) functionalized graphene nanocomposite modified electrode for detecting of puerarin,

Talanta,

Volume 174

77.  Dong, Qingying, et al. "Comparative study on phenolic compounds, triterpenoids, and antioxidant activity of Ganoderma lucidum affected by different drying methods." Journal of Food Measurement and Characterization 13.4 (2019): 3198-3205.https:##doi.org/10.

76.  Dong, Qingying, et al. "Comparative study on phenolic compounds, triterpenoids, and antioxidant activity of Ganoderma lucidum affected by different drying methods." Journal of Food Measurement and Characterization 13.4 (2019): 3198-3205.https:##doi.org/10.

75.  Qian, Suhong, et al. "Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity." Viruses 7.4 (2015): 1613-1626.https:##doi.org/10.3390/v7041613

74.  Yang, Jing, et al. "Determination of active compounds in raspberry leaf extracts and the effects of extract intake on mice." Food Science and Technology 40 (2019): 124-131.https:##doi.org/10.1590/fst.35518

73.  Pei Pu, Xin Zheng, Linna Jiao, Lang Chen, Han Yang, Yonghong Zhang, Guizhao Liang, Six flavonoids inhibit the antigenicity of β-lactoglobulin by noncovalent interactions: A spectroscopic and molecular docking study, Food Chemistry, Volume 339, 2021, 128106

72.  Song, Hongdong, et al. "Innovative assistant extraction of flavonoids from pine (Larix olgensis Henry) needles by high-density steam flash-explosion." Journal of agricultural and food chemistry 62.17 (2014): 3806-3812.https:##doi.org/10.1021/jf405412r

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